Dad and baby

Activated B. infantis EVC001 combined with human milk is the bacteria infants need to train the immune system

PEER-REVIEWED RESEARCH

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Feeding Evivo (activated B. infantis EVC001) in the first 100 days of life reduces potential pathogens, linked to higher risk of autoimmune and allergic diseases

Peer-reviewed research in Cell demonstrates that colonization with the specific strain activated B. infantis EVC001 significantly lowers intestinal inflammation and pivots immune system development away from phenotypes linked with allergy, asthma, and autoimmune diseases.

Activated B. infantis EVC001 Guides Early Immune System Development

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Activated B. infantis EVC001 colonization significantly lowers intestinal inflammation and immunoregulates CD4+ T cells implicated in autoimmune and allergic diseases in children. Feeding activated B. infantis EVC001 in the first months of life influences immune activation by:

  • Decreasing intestinal inflammation 

  • Upregulating IFNb, which improves the body's natural ability to control inflammation 

  • Silencing intestinal Th2 and Th17 cells which are associated with development of autoimmune and allergic diseases (NCD) in infants 

  • Polarizing T-cells to Th1-type cells which are associated with proper immune development 

Early Microbiome Composition Impacts Immune Development 

Immune Development Chart

 

There has been a significant rise in autoimmune and allergic diseases in infants and children since the 1950s

Type 1 Diabetes

Rates of multiple sclerosis, Crohn's disease, Type 1 Diabetes, and asthma have increased 300% and allergies have followed a similar trend

Colic

According to the CDC, 8% of children in 2020 had at least one food allergy, and 7.5% suffer from asthma

Eczema

13% of children now have atopic dermatitis, a chronic form of eczema

Gut microbiome

Infants have a sterile gut at birth which quickly becomes colonized by bacteria that influence the composition of the gut microbiome. The key native infant gut bacteria, B. infantis, is missing in more than 90% of babies born in the U.S. today as a result of lifestyle changes and medical practices, including the use of antibiotics and C-section deliveries.

There is an ordered sequence of immune changes after birth driven by microbial interactions. The first 100 days of life provide a window for intervention to positively influence programmable (na"ive) immune cells. Feeding Evivo is clinically proven to pivot the immune system towards healthier immune development. 

Newborn Gut Deficiency and the Developing Immune System 

LEARN MORE

Read the Publication: Henrick et al. (2021) Cell doi:10.1016/j.cell.2021.05.030

Bifidobacteria-mediated immune system imprinting early in life 

Key Takeaway

The first 100 days of life is a critical window to influence immune system development in your infant patients. Feeding Evivo (activated B. infantis EVC001) during this timeframe leads to healthier immune system development, providing the opportunity to reduce the risk of allergic and autoimmune conditions for your patients later in life.

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