Peer Reviewed Scientific Publications

Bifidobacterium infantis EVC001 Administration Is Associated With a Significant Reduction In Incidence of Necrotizing Enterocolitis In Very Low Birth Weight Infants

Impact of Probiotic Bifidobacteria infantis EVC001 Feeding in Premature Infants on the Gut Microbiome, Nosocomially Acquired Antibiotic Resistance, and Enteric Inflammation

Study quantifies unprecedented reduction in enteric inflammation, diaper rash and antibiotic use via bene

B. infantis EVC001 Is Well-Tolerated and Improves Human Milk Oligosaccharide Utilization in Preterm Infants in the Neonatal Intensive Care Unit

Article Bifidobacteria-mediated immune system imprinting early in life

A lack of bifidobacteria and/or their genes required for the utilization of human milk oligosaccharides from breast milk is associated with systemic inflammation and immune imbalance early in life.

Symptomatic relief from at-home use of activated Bifidobacterium infantis EVC001 probiotic in infants: results from a consumer survey on the effects on diaper rash, colic symptoms, and sleep

Metagenomic insights of the infant microbiome community structure and function across multiple sites in the United States

The gut microbiome plays an important role in early life, protecting newborns from enteric pathogens, promoting immune system development and providing key functions

Comparative Genome Analysis of Bifidobacterium longum subsp. infantis Strains Reveals Variation in Human Milk Oligosaccharide Utilization Genes among Commercial Probiotics

Provides evidence of the functional implications of genetic differences among B.

Colonization by Bifidobacteria infantis EVC001 modulates enteric inflammation in exclusively breastfed infants

A clinical study published in the journal Pediatric Research shows that colonizing infants with

Evivo Clinical Study Summary

12/6/2017 — The bacteria in Evivo, Bifidobacterium longum subsp. infantis (B. infantis) is the critically important bacteria in baby’s gut microbiome early in life.

Early-life gut microbiome modulation reduces the abundance of antibiotic-resistant bacteria

Colonization of the gut of breastfed infants by a single strain of B. longum subsp. infantis had a profound impact on the fecal metagenome, including a reduction in ARGs.

New Study Reveals Activated Bifidobacteria Infantis EVC001 Reduces Colonic Mucin Degradation in Babies

Study results showing that breastfed babies colonized by Bifidobacterium longum subsp. infantis EVC001 displayed significantly less evidence of mucin degrada

Alarming Increase In pH of Babies' Stool Indicates Loss of Critical Good Bacteria

A healthy gut microbiome is connected to everything from digestion to cognition to immunity and begins the day you are born.

Integrating the Ecosystem Services Framework to Define Dysbiosis of the Breastfed Infant Gut: The Role of Bifidobacteria infantis and Human Milk Oligosaccharides

Colonization Resistance in the Infant Gut: The Role of Bifidobacterium infantis in Reducing pH and Preventing Pathogen Growth

Infant Fecal pH Revealed as a Critical Indicator of Infant Gut Health and Resistance against Gut Pathogen Invasion

N-glycans from Human Milk Glycoproteins are Selectively Released by an Infant Gut Symbiont In Vivo

Bifidobacterium infantis has unique enzymes that allow it to utilize special carbohydrates attached to proteins found in both human breastmilk and infant formula, called

Arguments for routine administration of probiotics for NEC prevention

The preponderance of evidence suggests that probiotic administration to premature infants is well tolerated and decreases the risk of death, necrotizing enterocolitis, and sepsis.

Genomic variation and strain-specific functional adaptation in the human gut microbiome  during early life

Data now show that the gut microbiome is highly involved in the development of the immune system during infancy and that the type of bacteria that make up the infant gut microbiome

Colonization of breastfed infants by Bifidobacterium longum subsp.

Bifidobacterial Dominance of the Gut in Early Life and Acquisition of Antimicrobial Resistance

 This study demonstrates that high levels of Bifidobacterium are associated with reduced levels of AMR in early life and suggests that probiotic interventions to increase infant Bifidobacterium l

A Comparison of Two Probiotic Strains of Bifidobacteria in Premature Infants

B. infantis was more effective at colonizing the fecal microbiota than B. lactose in both formula-fed and human milk-fed premature infants. The combination of human milk plus B.

Validating bifidobacterial species and subspecies identity in commercial probiotic products

Given the known differences between various bifidobacterial species and subspecies in metabolic capacity and colonization abilities, the prevalence of misidentified bifidobacteria in these produc

Prospects for Primary Prevention of Type 1 Diabetes by Restoring a Disappearing Microbe 

 The authors hypothesize that restoring B. infantis colonization early in infancy will prevent childhood-onset type 1 diabetes through effects on immune training, prevention of dysbiosis an

Infant Colic Represents Gut Inflammation and Dysbiosis

 Colic is linked with gut inflammation (as determined by fecal calprotectin) and dysbiosis, independent of mode of feeding, with fewer Bifidobacilli.

Bifidobacterium Abundance in Early Infancy and Vaccine Response at 2 Years of Age

New research out of UC Davis shows that the presence of B. infantis in baby’s gut during early infancy significantly improves the protec

Intrapartum antibiotics for GBS prophylaxis alter microbiome colonization patterns

Antibiotics can take a toll on our digestion and the good bacteria in our gut. Did you know that the antibiotics you take can affect your newborn baby’s gut microbiome, too?

Safety & Tolerability Summary

5/30/2017 — One key beneficial bacteria is designed by nature to live in babies’ gut, and thrive in the presence of human breast milk: Bifidobacterium (including B. infantis).

Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut

 The advantages of B. infantis, selected through coevolution with human milk glycans, present an opportunity for focused manipulation of the infant intestinal microbiota.