Bifidobacteria-mediated immune system imprinting early in life

This study identified a correlation between low Bifidobacteria abundance in infant gut microbiome and increased systemic and enteric inflammation. In vitro studies showed fecal metabolites from infants who were colonized with B. infantis EVC001 polarize naïve CD4 T cells away from Th17 (autoimmune) and Th2 (allergic) phenotype towards Th1 (tolerogenic).