Diaper rash is an early indicator of gut dysbiosis or pathogen overgrowth. The pH of the colon is determined by the type of bacteria that are present with pathogens thriving at a pH above 5.5. Not only does stool pH above 5.5 leads to the activation of fecal enzymes which cause skin irritation of the diaper area, more importantly, it allows the pathogens that have been linked to more severe autoimmune and allergic disorders, such as eczema, asthma, food allergies and Type 1 diabetes to thrive.
Based on this growing body of evidence, LabCorp national diagnostic lab has recently updated the infant stool pH reference range to pH 4.5-5.5, corresponding to the observed benefits within this range.
Emerging data now suggest that diaper rash may be an early indicator of gut dysbiosis or an overgrowth of pathogenic bacteria in the infant gut microbiome. Dysbiosis has been linked to many autoimmune and allergic disorders later in life and recognizing diaper rash as a symptom of this condition may allow for early and effective intervention during the early months of immune development.
Diaper rash is caused in large part by an elevation in skin pH, rather than a more acidic pH as commonly believed. In 1955, the average pH of the perianal skin in breastfed infants has been reported to be between 5.3-5.552. However, prolonged exposure of the perianal region to urine and feces leads to a more alkaline pH, increasing the risk for diaper rash53. Fecal pH also plays a significant role in the development of diaper rash, in that fecal enzymes, which are activated by elevated pH, have a direct irritant effect on the skin54.
Bifidobacterium longum subsp. infantis (B. infantis) lowers the pH of the stool through the production of lactate and acetate, thereby suppressing the growth of pathogens and deactivating skin irritating fecal enzymes. Only Evivo is activated B. infantis, EVC001. Evivo is clinically proven to effectively restore B. infantis leading to an 80% reduction in gut pathogens and a fecal pH linked to reduced incidence of diaper rash.
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