Evivo brings a protective system back to babies

Together, breast milk and B. infantis EVC001, the single bacterial strain in Evivo, protect baby from potentially harmful bacteria and helps support healthy immune function.

Evivo Powder

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A daily powder intended for babies fed any amount of breast milk to help establish a protective gut microbiome and support healthy immune function.

Clinically shown to:

  • Promote the growth of beneficial B. infantis EVC001 to establish a healthy gut microbiome
  • Protect from potentially harmful bacteria linked to colic, diaper rash, eczema, allergies, and type 1 diabetes
  • Significantly reduce gut inflammation
  • Convert breast milk HMOs into metabolites that help guide healthy immune function.

Clean Label Project certified. Safe & well tolerated by infants.

How does Evivo work with breast milk to protect babies from within?

See our documented mechanism of action.


B. infantis EVC001 uniquely captures Human Milk Oligosaccharides (HMOs) found in breast milk, helping infants maximize nutrition from breast milk.


B. infantis EVC001 then consumes HMOs to colonize, or to replicate, establish, and persist, in the gut and help protect baby from potentially harmful bacteria. These harmful bacteria have been linked to colic, digestive discomfort, eczema, allergies, and type 1 diabetes.


Finally, B. infantis EVC001 converts HMOs into metabolites, key signaling molecules that help guide healthy immune system function. An overactive immune system has been associated with the development of allergies and other autoimmune conditions later in life.

Evivo is Clean Label Project Certified

Clean Label Project is a national nonprofit committed to transparency in food and consumer product labeling. The organization runs lab tests on hundreds of products and awards those that surpass FDA regulations. Evivo powder passed the testing and received certifications for Clean Label Project.

Best-in-Class Product Standards

Evivo products are designated as a Food for Special Dietary Use (CFR21 part 105) and are Generally Recognized as Safe, or GRAS for infant use. We maintain best-in-class standards for product testing, manufacturing, packaging, and distribution:

  • Third-party testing ensures CFU (colony forming units) count and purity
  • Each manufacturing batch includes a Certificate of Conformance
  • All packaging is BPA free and protects Evivo from moisture, light, and oxygen

Since each baby is unique, you can choose the best way to feed Evivo.

1. Pour

Pour 1 sachet of Evivo powder into a small bowl or bottle.

2. Mix

Add breast milk or formula based on table. Mix well.

Feeding methodAmount of breast milk or formula per sachet
Spoon, oral syringe, or medicine dispenser pacifier1 tsp (approx. 5 mL)
Directly from finger, nipple, or pacifier5-10 drops (for paste)
BottleSingle feeding amount or 2 oz

3. Feed

Use immediately once mixed. Discard leftovers. Do not store for later use.


  • Give Evivo at the start of a feeding, so baby is likely to swallow more of it.
  • It’s ok if baby doesn’t finish everything during a single feeding, still discard the rest.
  • For best results, mix with room temperature or warm breast milk or formula. Some sediment is expected.
  • Hold or sit baby semi-upright, supporting the upper back and neck – just as if feeding a bottle. Don’t tip head back – this can make it harder to swallow.

We know how Evivo works and can support our claims with scientific evidence – that sets us apart from others.

Effects of probiotic and symbiotic supplementation on ponderal and linear growth in severely malnourished young infants in a randomized clinical trial

A single blind randomized clinical trial during the rehabilitation of <6-month-old infants with severe acute malnutrition in Bangladesh. Four weeks after the supplementation period, signs of improved ponderal growth (e.g. rate of weight gain and WAZ scores were significantly higher in infants who had been supplemented with the probiotic (B. infantis EVC001) for 28 days.

Preterm infant fecal microbiota and metabolite profiles are modulated in a probiotic specific manner

In this single-center observational cohort study demonstrates that supplementing an HMO-catabolizing Bifidobacterium probiotic (B. infantis EVC001) results in increased microbial metabolism of milk oligosaccharides and reduced intestinal inflammation relative to a non-catabolizing Lactobacillus probiotic in human milk-fed preterm infants

Bifidobacterium infantis EVC001 administration is associated with a significant reduction in incidence of Necrotizing Enterocolitis in very low birth weight infants

A retrospective observational analysis of two cohorts of very low birth weight (VLBW) infants (+/-) B. infantis EVC001) demonstrated that B. infantis EVC001 was associated with a significant reduction in necrotizing enterocolitis (NEC) and NEC-related mortality.

B. infantis EVC001 is well-tolerated and improves Human Milk Oligosaccharide (HMO) utilization in preterm infants in the neonatal intensive care unit

A prospective, open-label study was used to evaluate the tolerability and HMO-utilization capacity of B. infantis EVC001 and its effects on the fecal microbiota in thirty preterm infants <1,500 g and/or <33 weeks gestation at birth. B. infantis EVC001 was shown to be safe, well-tolerated, and efficient in colonizing the preterm infant gut and able to increase the abundance of bifidobacteria capable of metabolizing HMOs, resulting in significantly improved utilization of human milk.

Bifidobacteria-mediated immune system imprinting early in life

This study identified a correlation between low Bifidobacteria abundance in infant gut microbiome and increased systemic and enteric inflammation. In vitro studies showed fecal metabolites from infants who were colonized with B. infantis EVC001 polarize naïve CD4 T cells away from Th17 (autoimmune) and Th2 (allergic) phenotype towards Th1 (tolerogenic).

Impact of probiotic B. infantis EVC001 feeding in premature infants on the gut microbiome, nosocomially acquired antibiotic resistance, and enteric inflammation

An observational study in premature infants showing changes in microbiome composition, as well as significantly reduced antibiotic resistant gene abundance, enteric inflammation, diaper rash, and antibiotic use in infants fed B. infantis EVC001 compared to infants that were not fed the probiotic.

Symptomatic relief from at-home use of activated Bifidobacterium infantis EVC001 probiotic in infants: results from a consumer survey on the effects on diaper rash, colic symptoms, and sleep

A post-purchase consumer survey reported improvements in diaper rash, gassiness/fussiness, and sleep behavior in infants fed B. infantis EVC001

Comparative Genome Analysis of Bifidobacterium longum subsp. infantis strains reveals variation in human milk oligosaccharide utilization genes among commercial probiotics

Study finds important differences in the genetic makeup of commercial B. infantis strains, specifically on genes related to the metabolization of human milk oligosaccharides. Compared to H5 positive which are fully equipped, H5 negative strains are missing genes related to HMO uptake and attain lower density in vitro and in vivo in a proof-of-concept study.

Colonization by B. infantis EVC001 modulates enteric inflammation in exclusively breastfed infants

Analysis of fecal samples of a subset of infants from a randomized open-label trial to determine the effects of supplementing the probiotic Bifidobacterium longum subsp. infantis for the first 21 days finds 40d old control infants exhibit chronic enteric inflammation, which is significantly different from infants colonized with B. infantis EVC001.

N-glycans from human milk glycoproteins are selectively released by an infant gut symbiont in vivo

Analysis of fecal samples of a subset of infants from a randomized open-label trial to determine the effects of supplementing the probiotic Bifidobacterium longum subsp. infantis for the first 21 days. Study finds a significantly higher abundance of N-glycans released from milk glycoproteins in the infants fed EVC001 group compared with exclusively breastfed controls.

Early-life gut microbiome modulation reduces the abundance of antibiotic-resistant bacteria

Analysis of infants’ fecal samples from a randomized open-label trial to determine the effects of supplementing the probiotic Bifidobacterium longum subsp. infantis for the first 21 days finds an 80% reduction in the carriage of antibiotic resistance genes (ARGs) in infants colonized with B. infantis.

Colonization of breastfed infants byBifidobacterium longum subsp. infantis EVC001 reduces virulence gene abundance

Analysis of infants’ fecal samples from a randomized open-label trial to determine the effects of supplementing the probiotic Bifidobacterium longum subsp. infantis for the first 21 days finds a significant reduction of gut pathogens (identified by virulence factors) in infants colonized with B. infantis compared to those not fed the probiotic.

Reduced colonic mucin degradation in breastfed infants colonized by Bifidobacterium longum subsp. infantis EVC001

Analysis of fecal samples of a subset of infants from a randomized open-label trial to determine the effects of supplementing the probiotic Bifidobacterium longum subsp. infantis for the first 21 days of life find a significant reduction in mucous erosion in infants colonized with B. infantis EVC001 compared to those not fed the probiotic.

Persistence of supplemented Bifidobacterium longum subsp. infantis EVC001 in breastfed infants

Analysis of fecal samples of a subset of infants from a randomized open-label trial to determine the effects of supplementing the probiotic Bifidobacterium longum subsp. infantis for the first 21 days. A study finds a significantly higher abundance of B. infantis (by qPCR) and relative abundance of Bifidobacterium (by 16S rRNA sequencing) in infants fed with B. infantis EVC001 relative to the microbiome exclusively breasted control infants.

Safety and tolerability of Bifidobacterium longum subspecies infantis EVC001 supplementation in healthy term breastfed infants: a phase 1 clinical trial

Open-label clinical trial to determine the effects of supplementing the probiotic Bifidobacterium longum subsp. infantis EVC001 for the first 21 days of life in healthy term breastfed infants compared with matched-control term infants receiving standard care. B. infantis EVC001 was found to be safely consumed and well-tolerated. Stools were fewer and better formed in infants in infants fed EVC001 group compared with exclusively breastfed controls. Adverse events were those expected in healthy infants and not different between groups.

B. infantis EVC001 Sepia

Who is Evivo for?

The short answer—all babies.

Supporting you through the parenthood journey

Science shows that every baby fed any amount of breast milk can benefit from Evivo, especially newborns delivered by C-section, impacted by antibiotics, or showing colic symptoms. NICU personnel caring for the most vulnerable babies are also confident in administering Evivo to their patients.

Black father kissing forehead of newborn son

Did you know 9 out of 10 babies are missing B. infantis?
Despite scientific evidence showing B. infantis naturally belongs in babies to partner with breast milk, there has been a generational loss in the US due to high antibiotic and modernized feeding and birthing practices.

Evivo contains B. infantis EVC001.
We are determined to bring this natural system back to all babies with Evivo, which contains a powerful strain of B. infantis, EVC001, clinically shown to work with breast milk.

Does your baby have colic?
Scientists believe colic may be caused by an overabundance of harmful bacteria.

Evivo can help.
B. infantis EVC001, only in Evivo, reduces bad bacteria in baby’s gut microbiome by 80%. After using Evivo for one week, parents report relief and better sleep.

What happens with antibiotics?
Antibiotics kill bad bacteria but also the good, and may cause diarrhea and an upset stomach.

Evivo after antibiotics, restores the good.
Replenishing baby with beneficial B. infantis EVC001 re-establishes a protective gut environment deterrent to harmful bacteria and continues supporting healthy immune function.

Implications of C-section births.
Babies born by C-section lack beneficial bacteria picked up through the birthing process, and are exposed to antibiotics.

Begin Evivo with the first breastfeeding.
Populating baby’s gut with B. infantis EVC001 during a key time for immune system education can have massive health impacts.

Safe for infants in the NICU.

In the NICU, babies are often exposed to necessary, life-saving medicines that may unintentionally negatively affect their gut microbiome. As their immune systems are not fully developed, they are also at higher risk of infection caused by harmful gut bacteria.

Evivo’s NICU infant probiotic can help.

With 80% of our immune system in our gut, how you care today for baby’s gut microbiome matters.

Loved by parents

This was life-changing for us

My poor baby had such bad colic, always uncomfortable and unsettled. Within 4 days of regular use everything changed. My baby is finally a happy baby! Additionally, his sleep schedule is much more regular and I’m getting a nice stretch of sleep! My baby doesn’t always love taking it with the dropper but it’s worth it, if I could go back my only change would be to take this sooner!

Tiffany O.

So helpful!

Baby in NICU

My daughter ended up being in the NICU after she was born because she had fluid in her lungs which turned into pneumonia. She was put on a 5-day course of antibiotics. We brought her home and we knew she needed a good probiotic. We started using Evivo and she was less gassy and slept longer. We could tell her stomach was less bloated and she had less discomfort. She also started having a bowel movement at least once a day. Huge difference from when we originally brought her home. Highly recommend.

Kathleen Z.
New York

Everything we wanted... and more!

My baby was delivered via c-section and after dealing with multiple issues, including severe reflux, thrush, etc, we were desperate to find a probiotic that could give our baby the peace she needed… and we found that in Evivo! We saw a difference within two weeks, and now at 4 months, our baby girl is shining! Bye bye throw-ups after every feed, so long thrush… and helloooo strong, healthy, warrior child! Thank you, Evivo, for providing such a life-changing, quality product… our baby girl is shining because of you!

Jamie S.
United States

So much relief for my little guy!

Baby in NICU

Evivo has been exactly what my little guy needed! After spending his first 3 weeks of life in the NICU and having multiple rounds of antibiotics, his digestive system was not functioning normal and I knew his gut health needed help. After trying a few probiotics without any change, I finally tried Evivo and I wish I would’ve started here! His digestive system is functioning normal and he seems so much more comfortable all day long. So thankful for this company!

Lisa R.

Life changing for us

I can’t recommend Evivo enough! My baby was pooping 8-12 times a day and in terrible pain each time. He was gassy and fussy all day. It was taking all the joy out of being a new mom! Within 3 days of starting Evivo we started to see changes. Our baby was happier, had 3-4 stools a day, less gas, and he even slept better. This was a life changer for us! I recommend Evivo to all my friends with new babies and can’t thank the company enough for making this product. So, so happy my baby is no longer in pain and we can enjoy life together!

Hannah L.

Awesome for premature baby

Baby in NICU

My daughter was born, via C-Section, a month early due to some medical complications. Unfortunately, she had to spend 19 days in the NICU. Somehow her blood showed that she got an infection. Doctors aren’t sure how this happened when everything is so sterile.
The doctors immediately started an IV on our daughter and started her on antibiotics. From what I understand is that antibiotics potentially can kill good strains of gut bacteria. Having good gut health can help prevent autoimmune diseases and future health issues.
With me having 2 autoimmune diseases I wanted to help my daughter start this world on the right foot. So as soon as she got released from the hospital I started her on Evivo. My daughter is thriving and despite being born a month early is hitting and nailing every milestone as is she was born full term.

Melissa W.

Evivo for the win!

Now his gas passes easily, his bowel movements are under control, and thankfully (knock on wood) he has not gotten sick as of yet despite every other person in the house being ill. I’m forever thankful for this product and am about to reorder. If you’re on the fence just order! You’ll be happy you did.

Kacie W

Best investment!

Baby in NICU

I don’t have enough good things to say about this product!! It has done wonders for our baby girl!! She was in the NICU for a few days and given antibiotics, and I also was given antibiotics due to being GBS+. We dealt with so much fussiness and upset tummies, she had horrible reflux, she had watery stool (which I thought was normal!) then she had blood in her stool! Well, it’s been 3 weeks of this probiotic and we haven’t had one bloody stool diaper, we have had almost no tummy aches! Her diapers have gone from 10 poops to 1 healthy poop a day! And her reflux has minimized like crazy!

Kyana M.

We love Evivo

At 9 days old our newborn had a fever and was in the hospital for 3 days with a high dose of antibiotic. He already was fussy but he was miserable with a constant upset stomach and the worst diaper rash I have ever seen. We tried every cream and after doing some research we found Evivo. I tried a probiotic at Target that did nothing for the problem. After hours of screaming one night, we made the first purchase of Evivo. After a week the rash was almost gone and after 2 weeks he did not have colic or upset stomach. He went from pooping every hour to once every other day. We love Evivo and have recommended it to many friends.

Michael B.

Worth every penny!

Baby in NICU

As a microbiome scientist, I have known about Evivo for the past 2 years and have been impressed with the strength of the scientific evidence behind it. I purchased it for my daughter prior to her birth and she started taking it at 5 days old. She spent 2 days after her birth in the NICU and received 2 doses of IV antibiotics, so I worried this would wipe out any good bugs she received during vaginal delivery. However, now she is a very happy and healthy, minimally fussy baby, and I imagine Evivo helped with that! She regained her birth weight within a week of taking it. Proper establishment of the gut microbiome is critical to proper immune system education and development and Evivo has strong evidence that it does this in breastfed babies.

Dana W.

Complete game changer

Wow- I cannot recommend Evivo enough. It was a complete game changer for our baby who has had digestive issues since she was born. We tried 3 other pro/pre biotics before giving Evivo a try and although some of those helped, none worked like Evivo. One thing to note- it didn’t kick in automatically for us. In fact the first 3 days baby was very fussy, so much so I almost stopped the drops thinking she was allergic to them. After talking to the support line and a doctor, I learned it was her body clearing out her system and gave it one more day. Absolute game changer. She started nursing better, sleeping better, and was overall a happier baby. Thank you Evivo!!

Brianne H.

Evivo is awesome!

I have been raving and recommending it to all of my new Mommy friends ever since it improved my little guy’s behavior in just a couple days of being on it. I started my son on it at 4 weeks old after being up with him for many nights while he was restless with gas and an upset stomach and would need gripe water, belly rubs, pumping of his legs and warm baths just to release painful gas and have a bowel movement. He also had bad baby acne and sensitive skin. Within two days of being on Evivo his skin was completely cleared up and he was not whining and squirming with gas pains in the night and early morning. I would also say that with my first child, I did not know about Evivo and listened to her suffer for many months with these issues and I also suffered by having to give up certain foods and alter my diet. Since my son started Evivo, I have not had to limit or cut out any specific foods and he seems fine with it.

Jaimi-Lyn S.

Happy Baby!

During the delivery, we received five rounds of antibiotics and I didn’t think much of it. When I got home the experience was so much different than with my firstborn. She was irritable, had multiple bowel movements a day, seemed uncomfortable all the time and I just couldn’t understand what was going on in her tummy. I was giving her breast milk after all! I felt like it was what was causing her agony. I tried switching to formula and it backlashed, she broke out in a serious rash with…a suspected cow milk allergy. I cut all dairy from my diet In order to keep breastfeeding her. My lactation consultant recommended that I try introducing some probiotics back into her system…considering that we went through many rounds of antibiotics during delivery. I noticed a huge difference in her bowel movements! I’m very happy I decided to try this and I will continue to use it as long as I need to and as long as she needs it.

Lissett C.

Finally we can relax

We feel safe with Evivo. Our preemie was delivered via emergency c-section and spent 2 weeks on antibiotics. Evivo has truly helped this baby’s wrecked guts and we believe it’s continuing to do so. We feel good about that.

Julia F.

No more bloody stools, and no more crazy elimination diet!

My LO had bloody stools with gross blood every day since 3 weeks old, with no other symptoms – happy baby with healthy weight gain. The pediatrician suspected food protein intolerance and told me to eliminate problematic foods from my diet. By 3 months old, I was on a crazy elimination diet of no dairy, soy, egg, wheat, peanut, coconut, fish, shellfish, oats, rice, peppers, and all seasonings besides salt – still, nothing improved her situation. I was referred to a pediatric GI specialist who conducts probiotic research by my coworker, who recommended Evivo, as it contains the Bifidobacterium for populating the large intestine where she was showing inflammation. The change was obvious after only 2 days! No more blood and I’ve been able to slowly add all the foods back into my diet within 2 months!

Yaya L.

Love love love Evivo

My experience using Evivo was overall amazing! As a new mom, I didn’t know how to help my little one. Then I was introduced to Evivo! I was leary at first, but I could notice a huge difference with my baby girl. I recommend Evivo and mention it to all the mommas I know! Thank you, Evivo, you have been a lifesaver!

Malynda W.
West Virginia

Great product

Wonderful experience. My daughter was born extremely early 3 months to be exact and has had terrible gut issues she is now 8 months old and we have been using evivo since the start when our nicu doctor recommended it to us and it’s been a life changer!

Ashley R.

Individual results may vary. Evivo is intended for infants consuming some HMO in their diet. If you have questions concerning your baby’s health i.e allergies, immunocompromised, please consult with your physician before use.

Highly rated by healthcare professionals & scientists

Jennifer Bragg, MD

VP, Clinical Implementation

Carrie McGuckin

NICU Nurse
Associate Director of Corporate Excellence

I definitely recommend Evivo for both premature babies in the NICU as well as full term babies that are home already. B. infantis EVC001 in Evivo is the best partner to help your baby maximize the breast milk that you are giving to them.

Albert Antonio, DO
Director, Clinical Implementation

When Evivo combines with breast milk in the baby’s GI tract it creates a very protective environment, which leads to the reduction of potentially pathogenic harmful bacteria, and thereby reduces inflammation in baby’s GI tract.

Erin Qualter, MD
Director, Clinical Implementation

I recommend Evivo to all newborns because all babies should have B. infantis in their GI tracts, helping them maximize breast milk and helping them fend off harmful bacteria in the gut.

Payal Adhikari, MD
Director, Clinical Implementation

Dr. Michael Fitzgerald, MD.

Medical Director, Elmhurst NICU

Working with LBW and preterm infants post NICU discharge, prioritizing gut health is paramount. It affects not only our babies’ growth trajectory and immunity but also helps babies regulate themselves and establish those beautiful sleep cycles we are always striving for. Evivo has helped many of my patients do just that, tolerate their feeds, sleep better, and meet their highest potential.

Monika Resenauer DNP, NNP-BC
Developmental Nurse Practitioner

Becca Duar, Ph.D.

Associate Director, Product

Bruce German, Ph.D

Founder & Food Scientist
Distinguished Professor
UC Davis Food Science & Technology

Frequently Asked Questions

Your baby’s health is your priority, so you likely have questions. You can contact us directly at (844) 436-8486, email customerservice@evivo.com, or search our FAQs for an answer.

Evivo contains B. infantis, a natural infant-specific strain that has evolved with humans for millions of years to work with breast milk. Because of these characteristics Evivo provides superior colonization.  When combined with breast milk, Evivo works by favorably changing gut biochemistry to reduce potentially harmful bacteria and intestinal inflammation, both of which have been linked to increased risk of short- and long-term health problems. The combination of Evivo and breast milk creates a protective infant gut environment, creating a foundation for good health.

Babies can be fed Evivo immediately once they begin consuming breast milk.

Evivo is safe to use with either breast milk or formula. Evivo works best for breastfed or mix-fed babies that are receiving some amount of breast milk.

If your baby finishes an entire bottle during a single feeding, this feeding method may be best for them. Note that if your baby doesn’t finish the bottle, we recommend throwing away the leftovers after 30 minutes.

Evivo is a Food for Special Dietary Use and can be taken with other medicines and antibiotics. We recommend you take this information to your pediatrician to determine if Evivo is suitable for your baby .

No, it does not matter if baby was born vaginally or via cesarean. Regardless of delivery method, recent research indicates that 90% of babies in the U.S. are missing B. infantis potentially due to modern birthing and feeding practices.

Evivo is manufactured at a GMP facility in the USA, is gluten-free and non-GMO. Evivo contains no flavor additives, dyes, or preservatives. Our goal is to add only the components you’d expect to find in an infant’s healthy gastrointestinal tract.

Evivo contains milk and residual amounts of soy. If soy or milk is a concern, please consult your pediatrician before use.

Connect with us

Call us at (844) 463-8486 for customer service, support, and to learn more about our products.

Our Science

Our focus is understanding naturally intended synergies between microbiome and diet.

Our Story

How we discovered B. infantis EVC001 partners with breast milk to better health.

Our Strain

B. infantis EVC001 is the powerful single strain that matters for infants