Leveraging the microbiome for better health
Through our deep scientific understanding of the gut microbiome and nutrition during the earliest stages of life, we uncovered a bacterial strain that supports infant gut health.
Our Scientific Focus at Infinant Health
The once-in-a-lifetime window of opportunity
We believe that by focusing our science on the short, but vital, time of development for infants, we can have the greatest opportunity to make an impact on gut health.
The gut microbiome for good health
Understanding the gut microbiome’s development can have an impact on your child’s health. This community of tiny organisms in the digestive system is closely connected to the whole body and has a strong influence. During the early stages of life, especially when your baby’s body is undergoing rapid changes in the metabolism and immune system, the gut microbiome plays a crucial role.
Nature-intended synergies for human health
Our science aims to uncover natural synergies between bacterial strains and the human diet to support people along their development journey, starting with breast milk, and as they expand into other nutritional sources.
B. infantis EVC001
A single strain baby needs.
B. infantis EVC001 has a powerful synergy with breast milk
Research confirms breast milk promotes the growth of B. infantis EVC001 in the full-term infant gut. By utilizing Human Milk Oligosaccharides (HMOs) in breast milk, B. infantis EVC001 colonizes (replicates and persists) in the infant gut.
Why it matters
Unlike other probiotic strains, B. infantis EVC001 does not pass through but maintains a powerful presence in the gut. To date, no other clinical study has demonstrated a substantial and persistent beneficial change in the gut microbiome.*
B. infantis has almost disappeared in the U.S.
The big issue
Research shows B. infantis is missing in more than 90% of infants born in the U.S.. Over last few generations, high antibiotic use and changes to feeding and birthing practices have changed the infant gut microbiome.3
Why it matters
In places like the US, where there aren’t as many babies with B. infantis in the gut, there tends to be more cases of immune-related issues. Having a lot of Bifidobacterium, especially B. infantis, in the gut seems to be like having a shield that protects against these problems.
- Frese, Steven A., et al. “Persistence of supplemented Bifidobacterium longum subsp. infantis EVC001 in breastfed infants.” MSphere 2.6 (2017): e00501-17.
- Casaburi, G., et al. (2021) “Metagenomic insights of the infant microbiome community structure and function across multiple sites in the United States.” Scientific Reports.doi.org/10.1038/s41598-020-80583-9
- Smilowitz JT, et al “Safety and tolerability of Bifidobacterium longum subspecies infantis EVC001 supplementation in healthy term breastfed infants: a phase I clinical trial”. BMC Pediatr. 2017 May 30;17(1):133. doi: 10.1186/s12887-017-0886-9. Erratum in: BMC Pediatr. 2017 Aug 15;17 (1):180. PMID: 28558732; PMCID: PMC5450358.
- Karav, Sercan, et al. “N-glycans from human milk glycoproteins are selectively released by an infant gut symbiont in vivo.” Journal of Functional Foods 61 (2019): 103485.
- Dimitratos, S. M., et al. “Symptomatic relief from at-home use of activated Bifidobacterium infantis EVC001 probiotic in infants: Results from a consumer survey on the effects on diaper rash, colic symptoms, and sleep.” Beneficial Microbes 12.4 (2021): 333-340.
- Reyman, M., van Houten, M.A., van Baarle, D. et al. “Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life”. Nat Commun 10, 4997 (2019). https://doi.org/10.1038/s41467-019-13014-7
- Martin JA, Hamilton BE, Osterman MJK. “Births in the United States, 2016”. NCHS data brief, no 287. Hyattsville, MD: National Center for Health Statistics. 2017
Connect with us
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