The Bacteria Babies Need

By Kristin Lawless, New York Times Correspondent | June 17, 2018

Probiotics and breastfeeding reduces potential antibiotic resistance in children

We may be missing the key to one of the biggest boons to public health since the introduction of iodine into the food supply in 1924.

Scientists at the University of California, Davis, have found that a strain of bacteria called B. infantis that is thought to have been the dominant bacterium in the infant gut for all of human history is disappearing from the Western world. According to their research, this was probably caused by the rise in cesarean births, the overuse of antibiotics and the use of infant formula in place of breast milk.

Indeed, nine out of 10 American babies don’t harbor this bacterium in their gut, while researchers suspect that the majority of infants in less industrialized countries do...Read more on NYtimes.com

Evolve BioSystems Announces $40 Million Series C Financing to Expand its Flagship Infant Probiotic Product Evivo®

Evolve BioSystems Announces $40 Million Series C Financing

Davis, California, June 13, 2018 – Evolve BioSystems, Inc., the leading infant gut microbiome company, today announced that it has completed a $40 million Series C round of funding co-led by the Bill & Melinda Gates Foundation, and Horizons Ventures, the venture division of the Li Ka Shing Foundation.

Read more...

Evivo Clinical Trials Summary

Persistence of Supplemented Bifidobacterium longum subsp. infantis EVC001 in Breastfed Infants

Pediatrician with Evivo baby

12/6/2017 — The bacteria in Evivo, Bifidobacterium longum subsp. infantis (B. infantis) is the critically important bacteria in baby’s gut microbiome early in life. It helps to program metabolism and the immune system and supports the complete digestion of nutrients.

Unfortunately, due to generations of modern medical practices such as antibiotics and C-sections, most babies no longer acquire B. infantis  early in life. Without it, potentially harmful bacteria thrive which have been linked to higher risk of colic, eczema, allergies, diabetes, and obesity. To date, probiotics have focused on general gut health and digestion, but until now had not demonstrated the ability to reduce potentially harmful bacteria.

In a controlled clinical trial led by University of California, Davis Medical Center, breastfed babies were given Evivo (activated B. infantis EVC001) once a day and compared to a similar group of babies who did not receive Evivo.  This study showed the first-ever restoration of the baby gut microbiome via Evivo. Babies given Evivo saw a 79% increase in bifidobacteria. These Evivo babies also experienced an unprecedented 80% reduction of groups of potentially harmful bacteria such as E. coli, clostridia, Staphylococcus (Staph), and Streptococcus (Strep), which have been linked to disease later in life.  Finally, across all babies in the study, those high in bifidobacteria had four times lower levels of endotoxin, a compound known to cause inflammation.

In summary, providing Evivo to babies in this clinical study completely restored the naturally protective gut microbiome in 100% of breastfed babies and significantly reduced potentially harmful groups of bacteria compared to babies who didn’t receive Evivo.

To read this article in full:   

 

These data have been presented at major international medical and scientific conferences, and have been published in peer-reviewed journals. Key presentations include:

American Academy of Pediatrics (AAP) 2016

“The Infant Microbiota and Probiotic Intake (IMPRINT) Study: Safety and Tolerability of Consuming Bifidobacterium longum subspecies infantis in Exclusively Breastfed Term Infants”.      

Pediatric Academic Society (PAS) 2017

American Academy of Pediatrics (AAP) 2017

Resources for Professionals

  • Restoring Infant Gut Microbiome Video

    Evivo is the only infant probiotic to substantially and persistently transform the infant gut microbiome

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  • Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants

    Intrapartum antibiotics for GBS prophylaxis alter colonization patterns in the early infant gut microbiome of low risk infants

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  • Restoring-Infant-Gut-MicrobiomeNIC-Winter-2018-Probiotics-for-Hospital-Use

    Probiotics for Hospital Use: Choosing the Right Strain, Right Food and Right Form

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  • Evivo-Safety-20-and-Tolerability

    Evivo™ was safely consumed and well-tolerated in a controlled clinical trial.

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  • Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut

    Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut

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  • Nature’s first functional food Breast milk feeds helpful microbes, fights harmful ones, provides immunity, and jump-starts a newborn’s life

    Breast milk feeds helpful microbes, fights harmful ones, provides immunity, and jump-starts a newborn’s life

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  • Restoring-Infant-Gut-Microbiome

    97% of babies no longer acquire B.infantis, allowing for potentially harmful bacteria to dominate the gut. Learn more.

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  • Restoring Infant Gut Microbiome Video

    Elevated Fecal pH Indicates a Profound Change in the Breastfed Infant Gut Microbiome Due to Reduction of Bifidobacterium over the Past Century

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