Alarming Increase In pH of Babies' Stool Indicates Loss of Critical Good Bacteria

Pediatrician with Evivo baby

A healthy gut microbiome is connected to everything from digestion to cognition to immunity and begins the day infants are born. We now know that the balance of good and bad bacteria in an infant’s gut directly impacts the pH levels of their stool. In this paper, the authors used the pH of infants’ stool to track how the infant gut microbiome has changed drastically over time.

First, there is a link between the type of bacteria in an infant’s gut and the pH of their stool: high levels of Bifidobacterium, the critical beneficial bacteria infants need for proper development of the immune system and metabolism, led to a lower fecal pH, while high levels of potentially harmful bacteria led to an elevated fecal pH. Next, using data previously reported on over 300 breastfed babies, there is an alarming increase in fecal pH over the past 100 years in developed countries such as the US, indicating a loss of Bifidobacterium in the infant gut.

The study concluded that several generations of formula feeding, antibiotic use, and C-section delivery have disrupted the infant gut microbiome, causing most of the infants born in your care today to be missing the beneficial bacteria Bifidobacterium. In its place, other potentially pathogenic bacteria are allowed to thrive, resulting in a dramatic increase in the pH of infant’s stool. The good news is that this clinical provides another reason to start the infants in your care on Evivo…in addition to our previously published landmark clinical trial on substantially and persistently restoring Bifidobacterium in the infant gut. Together we can return fecal pH to healthy historical levels!

Evivo Clinical Trials Summary

Persistence of Supplemented Bifidobacterium longum subsp. infantis EVC001 in Breastfed Infants

Pediatrician with Evivo baby

12/6/2017 — The bacteria in Evivo, Bifidobacterium longum subsp. infantis (B. infantis) is the critically important bacteria in baby’s gut microbiome early in life. It helps to program metabolism and the immune system and supports the complete digestion of nutrients.

Unfortunately, due to generations of modern medical practices such as antibiotics and C-sections, most babies no longer acquire B. infantis  early in life. Without it, potentially harmful bacteria thrive which have been linked to higher risk of colic, eczema, allergies, diabetes, and obesity. To date, probiotics have focused on general gut health and digestion, but until now had not demonstrated the ability to reduce potentially harmful bacteria.

In a controlled clinical trial led by University of California, Davis Medical Center, breastfed babies were given Evivo (activated B. infantis EVC001) once a day and compared to a similar group of babies who did not receive Evivo.  This study showed the first-ever restoration of the baby gut microbiome via Evivo. Babies given Evivo saw a 79% increase in bifidobacteria. These Evivo babies also experienced an unprecedented 80% reduction of groups of potentially harmful bacteria such as E. coli, clostridia, Staphylococcus (Staph), and Streptococcus (Strep), which have been linked to disease later in life.  Finally, across all babies in the study, those high in bifidobacteria had four times lower levels of endotoxin, a compound known to cause inflammation.

In summary, providing Evivo to babies in this clinical study completely restored the naturally protective gut microbiome in 100% of breastfed babies and significantly reduced potentially harmful groups of bacteria compared to babies who didn’t receive Evivo.

To read this article in full:   


These data have been presented at major international medical and scientific conferences, and have been published in peer-reviewed journals. Key presentations include:

American Academy of Pediatrics (AAP) 2016

“The Infant Microbiota and Probiotic Intake (IMPRINT) Study: Safety and Tolerability of Consuming Bifidobacterium longum subspecies infantis in Exclusively Breastfed Term Infants”.      

Pediatric Academic Society (PAS) 2017

American Academy of Pediatrics (AAP) 2017

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